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Physiologically Compatible Hemodialysis through Advanced Dialysate Regeneration

Award Information
Agency: Department of Education
Branch: N/A
Contract: H133S140070
Agency Tracking Number: H133S140070
Amount: $74,999.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-10-01
Award End Date (Contract End Date): 2014-03-31
Small Business Information
2611 SW Third Ave STE250F, Portlnd, OR, 97201-4957
DUNS: 799155523
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Takuji Tsukamoto
 (503) 352-0262
Business Contact
 Brian Bard
Title: Program Specialist
Phone: (202) 245-7345
Research Institution
The uremic syndrome is a disabling condition attributed to the progressive retention of solutes that would normally be excreted by the kidneys and which interact negatively with physiological systems/functions. These are broadly defined as uremic toxins. Hemodialysis treatment is prescribed for the majority of individuals in the final stages of renal failure. However, better dialysis options (length, frequency and location) are needed to enable individuals with this disability to work and engage in activities in their communities. With the goal of creating an advanced, portable hemodialysis system based on an innovative dialysate regeneration system, the investigators will use various surface chemistry techniques to develop an adsorption system effective for regenerating spent dialysate containing a wide spectrum of uremic toxins AND maintain nutrients such as amino acids, vitamins and essential ions. The technical objectives in the Phase I program are: 1) Design, Preparation and Characterization of the Advanced DRS; 2) Performance Characterization of the Advanced DRS for Uremic Toxin Clearance; 3) Efficacy and Safety Test on DRC Housing the Advanced DRS; 4) Summary of Phase I Program. The challenge in this Phase I project will be identifying an adequate balance between the degree of selectivity and the toxin removal effectiveness.

* Information listed above is at the time of submission. *

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