NOVEL ANTIMICROBIAL TREATMENT IN BURN GRAFT BIOMATERIALS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$133,386.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43GM064847-01
Award Id:
60955
Agency Tracking Number:
GM064847
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ACRYMED, INC., 12232 SW GARDEN PL, PORTLAND, OR, 97223
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BRUCEGIBBINS
(503) 624-9830
BGIBBINS@ACRYMED.COM
Business Contact:
JACKMCMAKEN
(503) 624-9830
JMCMAKEN@ACRYMED.COM
Research Institute:
n/a
Abstract
Collagen based biosynthetic materials have profoundly improved the outcome of reconstruction and restoration of congenital defects and traumatic injuries. This has been most apparent for massive burn victims that historically suffered lifelong severe scarring and lost of function following wound closure before the advent of these materials. Unfortunately the failure rate for biosynthetic implants is high, predominantly due to infection. This proposal intends to evaluate the feasibility of incorporating a silver technology directly into collagen biosynthetic scaffolding to impart short duration antimicrobial properties to prevent colonization during the first few critical days following surgical implantation. Currently, collagen implant failure rates exceeding 50 percent due to microbial growth lead to increased hospital stay, cause psychological distress to the patient, and retard healing and rehabilitation. In burns alone, over 51,000 Americans suffer could benefit from improvements in this material with additional benefits extending to plastic and reconstructive surgical applications that are increasingly using biosynthetic implants. It is the aim of this study to determine if antimicrobial activity can be incorporated into these important biomaterials for sustained release to control bioburden follow implantation.

* information listed above is at the time of submission.

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