Novel Leukocyte Receptor and Allograft Rejection

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI36755-1,
Agency Tracking Number: 24799
Amount: $75,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
291 N Bernardo Avenue, Mountain View, CA, 94043
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Curtis Ruegg
 (415) 964-6744
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will extend recent observations regarding the discovery and characterization of alloreaction-a-ssociated antigen (ARAg), a novel member of the immunoglobulin gene superfamily selectively expressedon leukocyte subsets. ARAg surface expression is increased on T lymphocytes in response to allogeneic,but not by mitogenic, stimuli and anti-ARAg monoclonal antibody (mAb) P1C5 specifically blocks thisalloactivation response in vitro. There are two aims of this proposal: 1) to provide evidence for theexistence of a putative ARAg counter-receptor (ARAg-CR) expressed which presumably interacts withARAg in transduction of important activation signals, and 2) to isolate a cDNA clone encoding the murinehomologue of ARAg. Soluble recombinant ARAg proteins will be engineered and used in flow cytometryassays to examine phenotypic expression of the putative ARAg-CR on relevant cell types. Evidence forthe existence of a putative ARAg-CR will provide an additional target for potential pharmacologicintervention. Molecular cloning of the murine ARAg homologue is essential for development of an animalmodel in which to evaluate candidate ARAg-based therapeutics in vivo. The long-term objective of thisproject is to develop ARAg-related reagents for their potential therapeutic value in allograft rejection andGVHD as well as autoimmune disease and reperfusion injury.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government