Activity-based protein profiling in ovarian cancer

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$140,000.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA101134-01A1
Award Id:
70553
Agency Tracking Number:
CA101134
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
11025 NORTH TORREY PINES ROAD, LA JOLLA, CA, 92037
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
EMME LIN
(858) 526-2509
EMMEL@ACTIVX.COM
Business Contact:
JOHN KOZARICH
(858) 526-2502
JOHNK@ACTIVX.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Activity-based probes (ABPs) for broad protein families will be used to identify novel protein targets and small molecule leads relevant to ovarian cancer. Because ovarian cancer is often asymptomatic during its early and most treatable stages, it is imperative to identify increasingly sensitive markers for this disease. Also, as treatment for ovarian cancer is highly invasive and often produces painful and debilitating side effects, there is a great need for the identification of novel drug targets, which may allow for the identification or creation of more effective and specific drugs to combat this disease. In Phase I of this project, ActivX Biosciences will apply its eXamine platform, which identifies active proteins in complex samples, to 10 human ovarian tumors and their matched normal tissues. Initially, ABPs for serine hydrolases and kinases will be used to detect proteins that display altered activities in the tumor samples relative to the normal samples. The ActivX bioinformatics platform will be used to acquire quantitative information about protein activities from the activity-based profiles. This bioinformatics platform will also link this data to known information from the clinical samples. In Phase II, at least 100 paired tumor and normal ovarian tissues will be analyzed for activity. The activity-based profiles of these specimens will be processed for information linking protein activity to clinical characteristics. Proteins exhibiting significant alterations in activity or linkage characteristics will be analyzed for their use as markers or drug targets for the diagnosis and treatment of ovarian cancer. The information gleaned from this study may be commercialized through partnerships and commercial agreements with pharmaceutical, biotechnology, and diagnostics companies. Such agreements typically contain license fees for the use of the technology in biomarker identification, drug-target identification, and cancer diagnostics, in addition to milestone and royalty payments.

* information listed above is at the time of submission.

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