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Novel flavonoids as anti-inflammatory agents in alcoholism

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AA021038-01
Agency Tracking Number: R43AA021038
Amount: $150,900.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAAA
Solicitation Number: PA11-096
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
KTRDC - U.K. - AgTecc Laboratories
Lexington, KY 40546-0236
United States
DUNS: 196165877
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JOHN LITTLETON
 (859) 257-1085
 john.littleton@uky.edu
Business Contact
 CINDY BURKLOW
Phone: (859) 257-1127
Email: cindy_burklow@yahoo.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): Flavonoids are ubiquitous secondary metabolites in plants with many known health benefits, which are mostly ascribed to their potent anti-oxidant activity. However, a search for novel nicotinic ligands, using high throughput pharmacological screening of a native plant extract library, and subsequently a pure flavonoid library, led to the highly surprising conclusion that some methoxylated quercetin-like flavonoid derivatives have partial agonist activity, selectively at the alpha7-subtype of nicotinic receptor for acetylcholine (nicAChR). Activation of these receptors on microglia and macrophages is known to reduce the release of inflammatory mediators by these cells, thereby reducing chronic inflammation in the CNS and peripheral tissues. Since there is a wealth of evidence which implicates chronic inflammatory changes in the neurodegeneration and organ damage associated with alcoholism, this implies that these specific flavonoids are of potential value for these

* Information listed above is at the time of submission. *

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