Increasing viability of lung organs for transplantation

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI109892-01A1
Agency Tracking Number: R43AI109892
Amount: $300,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: PA13-234
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
675 US Highway 1, North Brunswick, NJ, 08902-3378
DUNS: 803046676
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ZELIN SHENG
 (908) 246-9296
 zsheng@trim-edicine.com
Business Contact
 JIANJIE MA
Phone: (908) 246-9296
Email: jma@trim-edicine.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): While organ transplantation is a vital last resort therapy to treat patients with end-organ failure of the lung there is a growing waiting list of patients who are eligible for transplants as the number of suitable donor organs fall far short of the demand for these lifesaving procedures. Improving the preservation of donated organs so that a greater percentage would remain viable for use in transplant procedures represents an important area of unmet medical need in theUnited States. An agent to reduce ischemic damage to organs during transport will represent a technology that would enhance the protection of existing donors, expand the time window for surgical implementation, and potentially resuscitate marginal organs which could then be transplanted. The goal of this application is to examine the use of a tissue repair protein named MG53 in organ preservation for lung transplantation. Research and development efforts at TRIM-edicine have established that the recomb

* Information listed above is at the time of submission. *

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