A novel antisense therapeutic for treatment of Aspergillus fumigatus infections

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI112143-01
Agency Tracking Number: R43AI112143
Amount: $170,092.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: PA13-234
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
5750 SHIER-RINGS RD, DUBLIN, OH, 43016-1234
DUNS: 1004258
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 AUGUSTINE DINOVO
 (843) 573-0095
 gusdinovo@guildassociates.com
Business Contact
 MARCIE GAGNON
Phone: (614) 652-6003
Email: marcie@GuildAssociates.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): Guild proposes to develop an antisense oligomer-based antifungal effective against the human pathogen Aspergillus fumigatus. With a 40%-60% mortality rate, invasive aspergillosis (IA) due to A. fumigatus now surpasses invasive candidiasis as the most frequent fungal cause of death, especially amongst immunocompromised patients. Successful therapy for IA with current antifungals is notoriously difficult due to poor clinical efficacy and the increasing emergence of drug resistant strains. Despite this acute need for novel therapeutic strategies, there has not been a new class of antifungals targeting A. fumigatus developed in over 12 years. Therefore, a novel approach is urgently needed to develop new anti-Aspergillus targeting strategies. Phosphorodiamidate morpholino oligomers (PMOs), synthetic uncharged analogs of nucleic acids, are an antisense biotechnology that functions by base pairing with target gene mRNA, producing steric blockade of the translational machiner

* Information listed above is at the time of submission. *

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