A New Generation of Botulinum Toxin Vaccines

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI114044-01
Agency Tracking Number: R43AI114044
Amount: $225,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: PA13-234
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
100 LANCASTER AVENUE, LIMR Blad, Room R127, WYNNEWOOD, PA, 19096-3450
DUNS: 827553772
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 FETWEH AL-SALEEM
 (484) 476-2628
 fal-saleem@inventox.com
Business Contact
 LANCE SIMPSON
Phone: (484) 476-2628
Email: llsone@inventox.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): Botulinum toxin is one of the six categories of pathogens that have been designated as Category A Select Agents by the Centers for Disease Control. The toxin, which is generally acknowledged to be the most potent biological poison known, enters the body and acts on peripheral cholinergic nerve endings to cause paralysis of transmission. In seriously poisoned patients, this can include paralysis of the muscles of respiration, which can lead to death. A Presidential Blue Ribbon Panel has urged that medical countermeasures against the toxin be developed, including a vaccine against the toxin. There are 8 known serotypes of toxin (A to H), but only three of these account for almost all human illnesses (A, B, and E). Therefore, the Blue Ribbon Panel has proposed that highest priority be assigned to a trivalent A/B/E vaccine. Unfortunately, since the publication of the Panel's recommendations, there is not a single trivalent vaccine that has obtained regulatory approval. In

* Information listed above is at the time of submission. *

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