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Development of SFS Fractionators

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AT008304-01
Agency Tracking Number: R43AT008304
Amount: $224,947.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCCIH
Solicitation Number: AT14-001
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
WOBURN, MA 01801-1720
United States
DUNS: 194643722
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 (781) 932-6933
Business Contact
Phone: (781) 932-6933
Research Institution

DESCRIPTION (provided by applicant): The screening of a complex mixture of analytes is not always successful in sensitive screens for specific activities. Often, specific activities are masked by interfering compounds or false positives are given by ubiquitous compounds that interact with all screens. This problem can be resolved by purification of the analytes. Such an approach is not only cost-prohibitive but will also result in biasing the isolation of analytes tha occur in higher concentrations. Conventional organic solvents are not always ideal for biomass extractions. These solvents can be difficult to remove from the compounds potentially exhibiting bioactivity and, thus can mask bioactivity in an assay. In order to enhance the drug and dietary supplement discovery process, we have developed and patented processes for the polarity-guided fractionation of plants and microbes (Castor et al., 1998, 2003) using supercritical fluid solvents. The overall goal of this research project is to develop a com

* Information listed above is at the time of submission. *

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