Optimization of bifunctional pharmacophores for the treatment of neuroblastoma.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA180264-01A1
Agency Tracking Number: R43CA180264
Amount: $225,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: PA13-234
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
554 MANAYUNK RD, MERION STATION, PA, 19066-1137
DUNS: 963660787
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DAVID BETTOUN
 (610) 348-3245
 dbettoun@haropharma.com
Business Contact
 DAVID BETTOUN
Phone: (610) 348-3245
Email: dbettoun@haropharma.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): Genetic alterations that maintain cells in a poorly differentiated state are a hallmark of many leukemia and childhood cancers. Among them, neural crest-derived neuroblastoma is the most prevalent cancer in infants andthe most common extracranial solid tumor in children with the majority of patients being 5 years old or younger. Approximately 650 neuroblastoma tumors of the sympathetic nervous system are diagnosed each year in the United States and 10,000 children a year worldwide. Although successfully managed in its milder forms, the 5-year survival rate for patients with high risk neuroblastoma under an aggressive therapeutic regimen is only 40% and is associated with a high morbidity. Safer and more effective treatments are needed to manage this condition. HaRo Pharmaceuticals, Inc. is developing a promising polypharmacological agent that affects two distinct but functionally interconnected cellular pathways, which have been shown to be important for the treatmen

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government