Optimization of bifunctional pharmacophores for the treatment of neuroblastoma.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA180264-01A1
Agency Tracking Number: R43CA180264
Amount: $225,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: PA13-234
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
DUNS: 963660787
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (610) 348-3245
Business Contact
Phone: (610) 348-3245
Email: dbettoun@haropharma.com
Research Institution
DESCRIPTION (provided by applicant): Genetic alterations that maintain cells in a poorly differentiated state are a hallmark of many leukemia and childhood cancers. Among them, neural crest-derived neuroblastoma is the most prevalent cancer in infants andthe most common extracranial solid tumor in children with the majority of patients being 5 years old or younger. Approximately 650 neuroblastoma tumors of the sympathetic nervous system are diagnosed each year in the United States and 10,000 children a year worldwide. Although successfully managed in its milder forms, the 5-year survival rate for patients with high risk neuroblastoma under an aggressive therapeutic regimen is only 40% and is associated with a high morbidity. Safer and more effective treatments are needed to manage this condition. HaRo Pharmaceuticals, Inc. is developing a promising polypharmacological agent that affects two distinct but functionally interconnected cellular pathways, which have been shown to be important for the treatmen

* Information listed above is at the time of submission. *

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