A Potent Small Molecule Chemokine Antagonist Blocks Tumor Cell Dissemination In V

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA183362-01A1
Agency Tracking Number: R43CA183362
Amount: $224,748.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: PA13-234
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
3805 OLD EASTON RD, DOYLESTOWN, PA, 18902-8400
DUNS: 962708579
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JOSEPH SALVINO
 (610) 256-6571
 jsalvino@alliancediscovery.com
Business Contact
 JOSEPH SALVINO
Phone: (610) 256-6571
Email: jsalvino@alliancediscovery.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): Evidence in pre-clinical and clinical settings suggests the involvement of chemokines in metastatic tumor cell disease spreading. We have recently provided data validating the involvement of the CX3CR1/Fractalkine axisin breast and prostate cancer metastasis. We have discovered a potent in vivo efficacious drug-like small molecule using in vitro chemotaxis and functional assays to provide pharmacological proof of concept that modulation of the CX3CR1/ Fractalkine axis with a small molecule CX3CR1 antagonist may have therapeutic benefit in the treatment of advanced breast and prostate cancer. Specific aims of this proposal are: Aim 1: To provide an improved drug-like CX3CR1 antagonist. The lead compound, JMS-17-2, will beoptimized using medicinal chemistry approaches; maintaining potency, improving selectivity, and optimizing in vitro pharmacokinetic properties and the resulting optimized lead from this aim will be evaluated for in vivo pharmacokinetics in mice and u

* Information listed above is at the time of submission. *

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