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Novel platform for isolation of rabbit monoclonal antibodies against modified RNA bases

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43DA038979-01
Agency Tracking Number: R43DA038979
Amount: $188,104.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIDA
Solicitation Number: DA15-001
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10151 Pacific Mesa Blvd.
SAN DIEGO, CA 92121-4329
United States
DUNS: 186489899
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (858) 768-8107
Business Contact
Phone: (785) 877-5703
Research Institution

DESCRIPTION (provided by applicant): RNA editing and post-transcriptional modification is emerging as a key epigenetic mechanism for fine tuning genetic diversity and RNA function of particular importance in the brain. However, while some RNA editing processes have been relatively well described, other RNA modifications are poorly understood and many questions remain about the true significance of these processes to neurological function in health and disease. Recent developments in deep sequencing approaches have highlighted the number and extent of RNA base modifications, but tools with the requisite high specificity are required to understand the role these changes play in neurophysiology at the developmental, regional, cellular and subcellular level. Inthis proof of concept Phase I study, we propose to use our cutting edge technology that combines the robust nature of the rabbit immune system with the power of yeast display technology to demonstrate the power of this approach to isolate highly specific,

* Information listed above is at the time of submission. *

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