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High Throughput Chromatin Immunoprecipitation on Formalin Fixed Paraffin Embedded

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43ES024114-01
Agency Tracking Number: R43ES024114
Amount: $224,830.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIEHS
Solicitation Number: ES13-009
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1914 PALOMAR OAKS WAY, SUITE 150
CARLSBAD, CA 92008-6509
United States
DUNS: 109145701
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 THERESA KELLY
 (760) 431-1263
 kelly@activemotif.com
Business Contact
 THERESA KELLY
Phone: (760) 431-1263
Email: kelly@activemotif.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): Epigenetic mechanisms regulate gene expression potential and alterations in epigenetic marks, such as DNA methylation and histone modifications, have been associated with a variety of diseases. Tissue samples (both research and clinical) are often preserved by formalin fixation and paraffin embedment (FFPE), which allows for long term storage in minimally controlled environments. However there can be significant variability in the preparation of FFPE samples and the preservation conditions are harsh, making FFPE samples challenging for sophisticated downstream analyses. Clinical FFPE samples are often accompanied by valuable information including, histology, treatment course and patient outcome, thus they are an incredibly valuable source for linking basic and clinical research. The goal of this Phase I proposal is to provide the feasibility studies to use or newly developed transposase associate chromatin immunoprecipitation (TA-ChIP) to localize DNA methylation and

* Information listed above is at the time of submission. *

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