Kidney Progenitor Cells in Regenerative Medicine

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43GM110837-01
Agency Tracking Number: R43GM110837
Amount: $149,212.00
Phase: Phase I
Program: SBIR
Awards Year: 2014
Solicitation Year: 2014
Solicitation Topic Code: NIGMS
Solicitation Number: PA13-223
Small Business Information
DUNS: 176458172
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 (210) 616-9515
Business Contact
Phone: (210) 616-9515
Research Institution
Project Summary: We have shown that rat and mouse metanephric mesenchyme (MM) and ureteric bud (UB) cells undergo reciprocal induction to form differentiated tubular epithelium and undergo vasculogenesis forming capillary-like structures in 3-dimensional culture. Because these kidney progenitor cell lines retain differentiation potential, they have enormous potential in state-of-the art areas of research including cell-based therapy, stem cell biology, tissue engineering, and other burgeoning fields in regenerative medicine. This proposal is designed to establish the efficacy of the progenitor cell lines in cell-based therapy to accelerate repair and recovery during acute kidney injury. Information derived from these studies will be used to further commercialize the cells and optimize distribution to the scientific community, fostering investigation in nephrogenesis and regenerative medicine. The following aims are proposed: Aim 1. To define differentiation potential of kidney embryonic progenitor cells in c

* Information listed above is at the time of submission. *

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