Kidney Progenitor Cells in Regenerative Medicine

Award Information
Agency:
Department of Health and Human Services
Amount:
$149,212.00
Program:
SBIR
Contract:
1R43GM110837-01
Solitcitation Year:
2014
Solicitation Number:
PA13-223
Branch:
N/A
Award Year:
2014
Phase:
Phase I
Agency Tracking Number:
R43GM110837
Solicitation Topic Code:
NIGMS
Small Business Information
PROBETEX, INC.
7418 JOHN SMITH, SUITE A, SAN ANTONIO, TX, 78229-6020
Hubzone Owned:
N
Woman Owned:
Y
Socially and Economically Disadvantaged:
N
Duns:
176458172
Principal Investigator
 VERONIQUE BARNES
 (210) 616-9515
 vlbarnes@probetex.com
Business Contact
 VERONIQUE BARNES
Phone: (210) 616-9515
Email: vlbarnes@probetex.com
Research Institution
 Stub
Abstract
Project Summary: We have shown that rat and mouse metanephric mesenchyme (MM) and ureteric bud (UB) cells undergo reciprocal induction to form differentiated tubular epithelium and undergo vasculogenesis forming capillary-like structures in 3-dimensional culture. Because these kidney progenitor cell lines retain differentiation potential, they have enormous potential in state-of-the art areas of research including cell-based therapy, stem cell biology, tissue engineering, and other burgeoning fields in regenerative medicine. This proposal is designed to establish the efficacy of the progenitor cell lines in cell-based therapy to accelerate repair and recovery during acute kidney injury. Information derived from these studies will be used to further commercialize the cells and optimize distribution to the scientific community, fostering investigation in nephrogenesis and regenerative medicine. The following aims are proposed: Aim 1. To define differentiation potential of kidney embryonic progenitor cells in c

* information listed above is at the time of submission.

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