Hair follicle nestin-expressing stem cells on a scaffold for nerve repair

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43NS086217-01A1
Agency Tracking Number: R43NS086217
Amount: $224,700.00
Phase: Phase I
Program: SBIR
Awards Year: 2014
Solicitation Year: 2014
Solicitation Topic Code: NINDS
Solicitation Number: PA13-234
Small Business Information
7917 OSTROW ST, SAN DIEGO, CA, 92111-3604
DUNS: 173844010
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (858) 654-2555
Business Contact
Phone: (858) 654-2555
Research Institution
DESCRIPTION (provided by applicant): Nestin-expressing stem cells of the hair follicle, discovered by our laboratory (Proc Natl Acad Sci USA 2003; 100:9658-61[1]), have been shown by our laboratory to be able to form neurons and other non-follicle cell types (Proc Natl Acad Sci USA 2005; 102:5530-4 [2]). Our laboratory has shown that the nestin-expressing stem cells from the hair follicle can effect repair of the peripheral nerve (Proc Natl Acad Sci USA 2005;102:17734-8 [3]) and spinal cord injury (Cell Cycle 2008; 7:1865-9 [4] and Cell Cycle 10, 830-839, 2011 [5]). Transgenic mice, in which the nestin promoter drives GFP (ND-GFP), were used to characterize the nestin-expressing hair follicle. The cells have very long processes extending from them as shown by confocal microscopy and differentiate into neuronal cells at high frequency as well as into multiple other non-hair follicle cells in vitro. The hair follicle sem cells differentiate into neuronal and glial cells after transplantation to the injured

* Information listed above is at the time of submission. *

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