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CometChip: Development of a high throughput DNA damage assay in hepatocytes

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R44ES024698-01
Agency Tracking Number: R44ES024698
Amount: $224,969.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIEHS
Solicitation Number: PA13-234
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
PO BOX 13501
RESEARCH TRIANGLE PARK, NC 27709-3501
United States
DUNS: 130427701
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 LESLIE RECIO
 (919) 544-4589
 lrecio@ils-inc.com
Business Contact
 JULIE BISHOP
Phone: (919) 281-1110
Email: jbishop@ils-inc.com
Research Institution
 Stub
Abstract

DESCRIPTION (provided by applicant): Thousands of new industrial chemicals are produced each year. Knowledge about the potential carcinogenicity of these compounds is therefore critical to public health. It is well-established that DNA damage can lead to the mutations that cause cancer. Therefore, being able to screen chemicals for their potential to damage DNA offers an effective strategy for improving public health. Several genotoxicity screens have been developed and are used today effectively with highthroughput screening technology. However, there remains a critical gap in the tools that we currently have available. Specifically, while man types of DNA damage can be detected using existing technologies, bulky DNA adducts remain undetectable. It is well-established that bulky lesions can be carcinogenic. For example, aflatoxin is known to play a major role in causing liver cancer around the world. Furthermore, polycyclic aromatic hydrocarbons present in our environment are known to increase the risk

* Information listed above is at the time of submission. *

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