Accurate accessible cloud software for protein folding for molecular biologists

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R44GM110814-01
Agency Tracking Number: R44GM110814
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2014
Solicitation Year: 2014
Solicitation Topic Code: NIGMS
Solicitation Number: PAR09-220
Small Business Information
3801 REGENT STREET, MADISON, WI, 53705-5202
DUNS: 130194947
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 STEVEN DARNELL
 (608) 237-3082
 darnells@dnastar.com
Business Contact
 THOMAS SCHWEI
Phone: (608) 237-3082
Email: toms@dnastar.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): Most drugs interact with protein molecules to elicit a cellular response. Traditional drug discovery is a laborious and expensive experimental process, so computational approaches to assess protein function and to accelerate the discovery process are in high demand. Virtual drug screening and structure-based drug design represent computational approaches that can be important to the modern drug discovery and development process. Both are reliant on high-resolution tertiary (3D) protein structures and are hampered by the slow and often unsuccessful methods of experimental structure determination. Protein structure prediction is poised to impact human health by accelerating the construction of high-confidence structural models of drug targets and biopharmaceuticals, which will help identify new therapeutic strategies. However, current methods are very limited in their ability to predict high-resolution models, which is preventing broad classes of therapeutics from being

* Information listed above is at the time of submission. *

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