You are here

Development of VPL Vaccine for RSV

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI109926-01
Agency Tracking Number: R41AI109926
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA13-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
9610 MEDICAL CENTER DR, STE 100
ROCKVILLE, MD 20850-6330
United States
DUNS: 965180610
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JORGE BLANCO
 (301) 294-8619
 j.blabco@sigmovir.com
Business Contact
 JORGE BLANCO
Phone: (301) 294-8619
Email: j.blanco@sigmovir.com
Research Institution
 UNIV OF MASSACHUSETTS MED SCH WORCESTER
 
55 LAKE AVENUE NORTH
WORCESTER, MA 01655-0002
United States

 () -
 Nonprofit college or university
Abstract

Project Summary Human respiratory syncytial virus (RSV) is recognized as the single most important viral cause of acute respiratory disease in infants and young children worldwide. Elderly populations and immunocompromised individuals are also at significant risk for serious RSV disease. Despite this very substantial disease burden imposed by RSV worldwide, there are no vaccines available. Several problems have impeded RSV vaccine development. First is safety. An early formalin-inactivated vaccine (FI-RSV)predisposed infants to more severe disease upon natural exposure to live virus resulting in concerns about the safety of all subsequently developed RSV vaccines, particularly nonreplicating vaccines. A second problem is a lack of understanding of requirements for stimulation protective responses making efficacy of new vaccine candidates difficult to predict. A third problem is the failure of RSV infections as well as many vaccine candidates to stimulate long-term, protective immune responses. This propos

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government