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New Class of Bright, Sharp, Tunable Near-Infrared Fluorophores for Flow Cyto

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI112302-01
Agency Tracking Number: R41AI112302
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2 DAVIS DR, STE 204
RESEARCH TRIANGLE PARK, NC 27709-0003
United States
DUNS: 78769570
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JAMES PITNER
 (919) 354-1053
 bruce@nirvanasciences.com
Business Contact
 RUSSELL THOMAS
Phone: (919) 354-1053
Email: Russell@nirvanasciences.com
Research Institution
 NORTH CAROLINA STATE UNIVERSITY RALEIGH
 
NORTH CAROLINA STATE UNIVERSITY RALEIGH SPONSORED PROGRAMS AND REGULATORY COMPLIANCE Administrative Services III 2701 Su
RALEIGH, NC 27695-0001
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): Polychromatic flow cytometry [FC] is one of the most powerful analytical techniques routinely used in immunology. Flow cytometry plays a critical role in several growing clinical applications: leukemia and lymphoma immunophenotyping for diagnosis and sub-categorization (now using 8-10 colors); in CD4/CD8 measurement in HIV-positive patients; and in HLA typing for transplantation cross-matching. With the increasing incidence of hematologic malignancies and use of transplantation, the number of FC tests will continue to grow as reliance on the methodology deepens. Increasing the number of fluorophores on a single sample will give clinicians a higher level of accuracy in the diagnosis and management of certain pediatric hematological disorders, where sample size is limited, and even allow for sub-categorization of the leukemia or lymphoma. Further utility of additional fluorophores for these polychromatic panels is for diagnostic samples of small volume such as specimens

* Information listed above is at the time of submission. *

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