Harvesting specific plant metabolites from hairy root cultures using magnetized n

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41AT008312-01
Agency Tracking Number: R41AT008312
Amount: $189,844.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCCIH
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
KTRDC - U.K. - AgTecc Laboratories, Lexington, KY, 40546-0236
DUNS: 196165877
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JOHN LITTLETON
 (859) 257-1085
 john.littleton@uky.edu
Business Contact
 CINDY BURKLOW
Phone: (859) 257-1127
Email: cindy_burklow@yahoo.com
Research Institution
 UNIVERSITY OF KENTUCKY
 UNIVERSITY OF KENTUCKY
109 KINKEAD HALL
LEXINGTON, KY, 40506-0057
 () -
 Nonprofit college or university
Abstract
DESCRIPTION: Plants produce a wide variety of valuable bioactive metabolites, but these are commonly present in low concentrations in the wild-type plant. This makes the separation and purification of these compounds complicated and expensive. The applicant company, Naprogenix Inc, has developed a technology for increasing the yields of specific bioactive metabolites in mutant plant cell cultures, which promises to lessen this problem. However, the value of this, or any other approach using genetically-modified plant cells, is limited by the necessity of the wasteful destruction of the plant cells in order to extract the required products. The process would be more efficient if products could be harvested from cells in continuous culture. Nanoparticles aretaken up by cells by endocytosis, and subsequently exocytosed. They can also be engineered to adsorb specific chemicals. This suggests that specifically-engineered (functionalized and magnetized) nanoparticles could be used to repeatedly harvest sp

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