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Ex vivo purging strategy for treatment of multiple myeloma

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA179706-01A1
Agency Tracking Number: R41CA179706
Amount: $160,632.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1 GREENWAY PLZ, STE 930
HOUSTON, TX 77046-0117
United States
DUNS: 831078428
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 GRANT MCFADDEN
 (352) 273-6852
 grantmcf@ufl.edu
Business Contact
 IMRE KOVESDI
Phone: (301) 963-1641
Email: imkovesdi@gmail.com
Research Institution
 UNIVERSITY OF FLORIDA
 
UNIVERSITY OF FLORIDA 219 Grinter Hall
GAINESVILLE, FL 32611-5500
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): The ultimate goal of this application is to develop a novel ex vivo purging method using myxoma virus (MYXV), a rabbit-specific poxvirus, to improve the clinical outcomes in treatment of multiple myeloma (MM). MM is aclonal plasma cell malignancy that has to date resisted essentially all therapeutic strategies. Currently, the standard of care for patients with MM is treatment with high-dose chemotherapy followed by autologous stem cell transplantation (ASTC). AlthoughASCT can often increase the disease-free interval for eligible patients, the disease generally relapses. This cancer relapse is mediated by cells derived from one or both of two sources: myeloma cells remaining within patient's hematopoietic system that resist the chemotherapy, and/or residual myeloma cells that contaminate the autologous stem cell graft sample. Recently, MYXV, when used to pre-treat primary MM patient ASTC samples, was found to be able to delete all residual MM cells while completely

* Information listed above is at the time of submission. *

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