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Orally available transition state inhibitors for triple negative breast cancer

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA183201-01
Agency Tracking Number: R41CA183201
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA13-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
50 E 8TH ST, STE 6N
NEW YORK, NY 10003-6524
United States
DUNS: 831297770
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 STEVEN ISAACMAN
 (646) 801-3872
 steve@nanometicslab.com
Business Contact
 STEVEN ISAACMAN
Phone: (646) 801-3872
Email: steve@nanometicslab.com
Research Institution
 ALBERT EINSTEIN COLLEGE OF MEDICINE
 
ALBERT EINSTEIN COLLEGE OF MEDICINE YESHIVA UNIV 1300 Morris Park Avenue
BRONX, NY 10461-1900
United States

 () -
 Nonprofit college or university
Abstract

Problem to be Solved: Triple-negative breast cancer (TNBC) is a deadly disease that accounts for 15-20% of all diagnosed breast cancers worldwide. Metastatic relapse of TNBC carries a poorer prognosis and lower survival rate compared to other breast cancersubtypes. Therefore, identifying novel targets and new therapeutics to treat patients diagnosed with TNBC remains a significant priority of the National Institutes of Health. Product and Long-Term Goal: Nanometics is developing a once daily, oral therapeutic, dubbed MTDIA for the treatment of TNBC. MTDIA inhibits a novel target, 5 -methylthioadenosine phosphorylase (MTAP), and disrupts biochemical pathways crucial for cancer growth. Technical Innovation: The MTAP enzyme is a promising new target for anti-cancer therapeutics because its systemic inhibition results in the whole-body accumulation of the 5'-methylthioadenosine (MTA) metabolite, which alters known anti-cancer pathways. Oral dosing with MTDIA is effective against both MTAP-positive and MTAP-n

* Information listed above is at the time of submission. *

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