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Validation of a Novel Treatment for Glioblastoma

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA186435-01A1
Agency Tracking Number: R41CA186435
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA14-072
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10225 BARNES CANYON RD, STE A104
SAN DIEGO, CA 92121-2734
United States
DUNS: 78816532
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 SANDEEP PINGLE
 (858) 337-1801
 sandeep.pingle@gmail.com
Business Contact
 GRAHAM BEATON
Phone: (858) 337-1801
Email: graham.beaton@curtanapharma.com
Research Institution
 UNIVERSITY OF CALIFORNIA SAN DIEGO
 
UNIVERSITY OF CALIFORNIA SAN DIEGO 9500 GILMAN DR, DEPT 0934
LA JOLLA, CA 92093-0934
United States

 () -
 Nonprofit college or university
Abstract

? DESCRIPTION (provided by applicant): The goal of this application is to study in vivo efficacy of CT102, a newly discovered inhibitor of the OLIG2 transcription factor in animal models of glioblastoma (GBM), a highly underserved area of pharmacotherapy. In this proposal, the experienced drug discovery group at Curtana Pharmaceuticals Inc. will conduct a pre-clinical evaluation of selectivity and in vivo distribution of CT102 to determine protocols for efficacy studies in orthotopic models of GBM. CT102 will be studied at UCSD to confirm potency of newly synthesized materials, assess activity in an orthotopic model of GBM and conduct in vitro and in vivo profiling to evaluate CT102 as a sensitizer to chemo- or radiotherapy. A successful outcome may result in a potential small molecule therapeutic for GBM. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The objective is to evaluate the efficacy of an inhibitor of the transcription factor, OLIG2 in pre-clinical animal models of glioblastoma, a

* Information listed above is at the time of submission. *

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