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Non-ATP competitive inhibitors of cyclin dependent kinases as cancer therapeutics

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41CA189620-01
Agency Tracking Number: R41CA189620
Amount: $224,898.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
166 CABIN DR, IRMO, SC, 29063-7756
DUNS: 79204540
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 CAMPBELL MCINNES
 (803) 576-5684
 mcinnes@sccp.sc.edu
Business Contact
 CAMPBELL MCINNES
Phone: (803) 338-6340
Email: mcinnes@ppipharma.com
Research Institution
 UNIVERSITY OF SOUTH CAROLINA
 UNIVERSITY OF SOUTH CAROLINA
COLUMBIA, SC, 29208-0001
 () -
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. This will be accomplished through application of this methodology to the discovery and characterization of new drug-like small molecule therapeutics disrupting interactions relevant to anti-cancer therapy. Improved strategies for developing pharmaceuticals based on inhibitors of protein-protein interactions would be beneficial in order to overcome the limitations ofthe majority of currently druggable targets to those involving ligand-receptor and enzyme-substrate interactions. We will focus our efforts on the Cyclin Dependent Kinase substrate recruitment site as a validated antitumor drug target. Through this si

* Information listed above is at the time of submission. *

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