You are here

DNP Polarization Agents for Real-Time Metabolic Imaging and Clinical Diagnosis

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA192567-01
Agency Tracking Number: R41CA192567
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA13-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
18 Copley St
Newton, MA 02458-2205
United States
DUNS: 832749092
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JOSEPH WALISH
 (414) 367-6679
 jwalish@dynupol.com
Business Contact
 JOSEPH WALISH
Phone: (414) 367-6679
Email: info@dynupol.com
Research Institution
 UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
 
UNIVERSITY OF CALIFORNIA SAN FRANCISCO 3333 California Street., Ste 315
SAN FRANCISCO, CA 94143-0962
United States

 () -
 Nonprofit college or university
Abstract

Project Summary / Abstract Although standard MRI techniques provide valuable structural insight, a related technique known as magnetic resonance spectroscopy (MRS) adds powerful real-time metabolic information about the tissues under study. MRS provides early detection of disease, monitoring treatment efficacy, and, in the case of cancer, a dramatic reduction in unnecessary biopsies. However, broad utilization of MRS in the clinic is hindered by the low sensitivity of the underlying nuclear magnetic resonance phenomenon. Dynamic nuclear polarization (DNP) dramatically enhances nuclear magnetic resonance signals by transferring polarization from relatively highly-polarized unpaired-electron spins to nuclear spins (e.g. 1H, 13C, 19F, 23Na, 31P). The unpairedelectrons are supplied by polarizing agents, which are persistent radical species added to a glass-forming matrix. Signal-to-noise ratio (SNR) improvements of over 10,000-fold are achievable with DNP. Hyperpolarized contrast agents and the high sensitivit

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government