Mitochondrial Uncoupling as a Therapeutic Target in Obesity

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41DK097862-01A1
Agency Tracking Number: R41DK097862
Amount: $183,070.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIDDK
Solicitation Number: PA13-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
209 AMERICAN PATH, GEORGETOWN, KY, 40324-8040
DUNS: 171691988
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PATRICK SULLIVAN
 (859) 323-4684
 patsullivan@uky.edu
Business Contact
 GREG JOHNSON
Phone: (859) 361-5678
Email: GJohn1957@aol.com
Research Institution
 UNIVERSITY OF KENTUCKY
 UNIVERSITY OF KENTUCKY
109 KINKEAD HALL
LEXINGTON, KY, 40506-0057
 () -
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Obesity is recognized as a national and global epidemic, as approximately 65% of adults in the United States are classified as overweight or obese as defined by body mass index (BMI). In fact, in the year 2000, the human race reached a historical landmark, when for the first time in history the number of adults with excess weight surpassed the number of those who were underweight. Obesity is linked with several cardiovascular risk factors cumulatively recognized as the metabolic syndrome. While obesity is associated with increased risk for metabolic syndrome and cardiovascular disease; consequently, weight loss in obese subjects has been demonstrated to reduce or reverse health risk factors. Fundamentally, irrespective ofthe method by which weight loss occurs, even a modest reduction in body weight has been shown to consistently reduce or reverse risk factors. In the 1930s it was recognized that increasing the body's basal metabolism using mitochondrial uncouplers, d

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