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Removal of Amyloid-beta Peptides from the Alzheimer's Brain

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AG046976-01A1
Agency Tracking Number: R41AG046976
Amount: $172,361.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIA
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
13 MONEY POINT ROAD
MYSTIC, CT 06355-3259
United States
DUNS: 27326496
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 HAIHAO ZHU
 (617) 638-4336
 wqiu67@bu.edu
Business Contact
 WEI WENDY
Phone: (617) 638-4336
Email: wqiu67@bu.edu
Research Institution
 BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
 
BOSTON UNIVERSITY 881 COMMONWEALTH AVENUE
BOSTON, MA 02215-1390
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): As the Alzheimer's disease (AD) population is growing rapidly, currently there are no cure treatments. The goal of this resubmitted STTR proposal is to conduct a preclinical study with pramlintide to prove a potential treatment for AD. We have revised the proposal significantly according to the reviewers' comments. Pramlintide is an FDA approved drug for diabetes and is an amylin analog. As diabetes increases the risk of AD, diabetic medications like pramlintide may be beneficial for AD as an off-label drug. Additionally, our preliminary study also suggests that amylin analogs may remove the neurotoxic amyloid-? peptide (A?) out of the AD brain. It is therefore imperative to study whether amylin and its analogs can be used as a drug for the treatment of AD. The goal of this STTR proposal is to evaluate the effect of pramlintide on the amyloid precursor protein transgenic (APP) mice, an AD mouse model. The central hypothesis of this study is that the pramlintide injection w

* Information listed above is at the time of submission. *

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