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Developing a Nrf2 activator for the treatment of scleroderma

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AR066418-01
Agency Tracking Number: R41AR066418
Amount: $224,858.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAMS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
855 N. WOLFE STREET SUITE 102
BALTIMORE, MD 21205-1503
United States
DUNS: 961692493
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 GRAHAM ALLAWAY
 (301) 461-7934
 graham@cureveda.com
Business Contact
 GRAHAM ALLAWAY
Phone: (301) 461-7934
Email: graham@cureveda.com
Research Institution
 NORTHWESTERN UNIVERSITY AT CHICAGO
 
NORTHWESTERN UNIVERSITY AT CHICAGO 750 N LAKE SHORE DR
CHICAGO, IL 60611-4579
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): Scleroderma is a devastating autoimmune disease with a chronic course, involving the overproduction of collagen leading to fibrosis of the skin and connective tissues. The disease has a range of symptoms including pain,stiffness and swelling of the joints, shortness of breath and gastrointestinal complications. More than 50% of patients with the aggressive form of scleroderma die or develop organ failure within five years and mortality rates have remained unchanged forfour decades. The majority (gt75%) of scleroderma patients are women, with initial diagnosis most commonly between the ages of 30 and 50. There are no approved treatments that target the underlying disease process, so current therapies focus on improving symptoms. These include anti-inflammatory drugs (corticosteroids and nonsteroidal anti-inflammatory drugs) and treatments for patient-specific symptoms. There is a major unmet need for more effective and disease- modifying therapies for scleroderma. The path

* Information listed above is at the time of submission. *

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