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Drug Delivery Method for Sudden Sensorineural Hearing Loss

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DC013534-01A1
Agency Tracking Number: R41DC013534
Amount: $222,527.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIDCD
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
5611 ROOSEVELT ST
BETHESDA, MD 20817-6739
United States
DUNS: 809594661
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BENJAMIN SHAPIRO
 (301) 405-4191
 benshap@umd.edu
Business Contact
 IRVING MD
Phone: (301) 346-7944
Email: inweinberg@gmail.com
Research Institution
 UNIV OF MARYLAND, COLLEGE PARK
 
Office of Research Administration 3112 LEE BUILDING
COLLEGE PARK, MD 20742-5141
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): The ultimate goal of the proposed project is to evaluate and commercialize a combination of proprietary magnet assemblies and magnetic nanoparticles (initially developed by our University STTR partner), that has been shown in preliminary animal studies to improve delivery of medications to the inner ear. Initial animal studies using the system (which uses magnetic forces to inject steroid-eluting magnetic nano-particles into the inner ear) have successfully reduced the degree of hearing loss and tinnitus in rats due to acoustic trauma. These initial studies suggest that the amount of steroids reaching the inner ear is increased ten-fold (compared to the current standard of trans-tympanic injection into the middle ear), without side effects. Our strategy is to demonstrate the utility of the magnetic injection system as a platform technology addressing the 4 billion hearing market, starting with a compelling clinical problem that currently is without a cure. Sudden Sen

* Information listed above is at the time of submission. *

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