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A Millimeter-wave Tunable Cavity for Ultra-sensitive Solids and Liquids DNP-NMR at Low Budget

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41AG050394-01A1
Agency Tracking Number: R41AG050394
Amount: $197,339.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIA
Solicitation Number: PA14-072
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
700 CLEMSON RD, COLUMBIA, SC, 29229-4339
DUNS: 45600368
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 FRANCIS DOTY
 (803) 788-6497
 david@dotynmr.com
Business Contact
 DAVID MCCREE
Phone: (803) 788-6497
Email: dave@dotynmr.com
Research Institution
 NORTH CAROLINA STATE UNIVERSITY RALEIGH
 NORTH CAROLINA STATE UNIVERSITY RALEIGH
SPONSORED PROGRAMS AND REGULATORY COMPLIANCE Administrative Services III 2701 Su
RALEIGH, NC, 27695-0001
 () -
 Nonprofit college or university
Abstract
? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding two orders of magnitude at ~100 K compared to conventional MAS-NMR in many biological solids. Despite this enormous benefit to biomedical research, the adaptation rate of DNP will be severely limited by its very high price tag (currently 1.8-4M), mostly because of the special magnet (with sweep coils) and expensive gyrotron required, owing to the very poor microwave efficiency of current DNP probes. Our detailed simulations of a novel millimeter wave (mmw) DNP cavity have shown the potential for achieving the needed electron spin saturation with two orders of magnitude lower microwave power than the existing MAS-DNP

* Information listed above is at the time of submission. *

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