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AutoRegister: A system for enhancing the accuracy of tumor change detection

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA183150-01A1
Agency Tracking Number: R41CA183150
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA13-235
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
CHELSEA, MA 02150-4021
United States
DUNS: 78509164
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (617) 959-1896
Business Contact
Phone: (617) 959-1896
Research Institution
Partners Research Management 101 Huntington Ave, Suite 300
BOSTON, MA 02199-7603
United States

 () -
 Domestic Nonprofit Research Organization

DESCRIPTION (provided by applicant): This project proposes to build an integrated software-based system for enhancing the accuracy of tumor change detection. The intent of the system, called AutoRegister, which is to be deployed on a clinical magnetic resonance imaging (MRI) scanner platform, is to automate the alignment of a patient's brain scan with that of a prior scan, such that subsequent offline tumor measurements do not have error introduced solely by differing slice orientation. While functionallysimilar to current auto-alignment technologies such as Siemens AutoAlign, the proposed technology is not sensitive to the inherent noise of such subject-nonspecific landmark- based techniques. Additionally the proposed technology is based upon a novel registration algorithm that is immune to outlier anatomy, such as a tumor, which often adversely affects techniques such as AutoAlign. In the United States, there are an estimated 13,000 deaths per year due to tumors in the primary central nervous system. Sta

* Information listed above is at the time of submission. *

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