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Cathepsin Inhibitors for Treatment of Breast Cancer Induced Bone Pain

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA192455-01
Agency Tracking Number: R41CA192455
Amount: $209,962.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCI
Solicitation Number: PA14-072
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1490 OBRIEN DR, STE G
MENLO PARK, CA 94025-1432
United States
DUNS: 790576180
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 LESLIE HOLSINGER
 (650) 833-5707
 leslie.holsinger@virobayinc.com
Business Contact
 LESLIE HOLSINGER
Phone: (650) 833-5707
Email: leslie.holsinger@virobayinc.com
Research Institution
 UNIVERSITY OF ARIZONA
 
UNIVERSITY OF ARIZONA PO BOX 210158, Room 510
TUCSON, AZ 85721-0158
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): The World Health Organization estimates that the number of women living with breast cancer globally will rise to 15 million by the year 2020 with a significant portion of these patients in advanced stages of the disease. Breast cancer is the most frequent malignant tumor in women in the U.S. with nearly 200,000 women diagnosed each year. The U.S. NIH estimate overall costs of cancer in the U.S. in 2006 to be 206.3 billion with 78.2 billion in direct medical costs. Breast cancer commonly metastasizes to the bone resulting in excruciating pain, bone remodeling and eventual bone fracture contributing to incapacitating pain and limited or total loss of mobility. A recent study in cancer patients demonstrated a significant and severe deficit in treatment options for cancer pain, with a much higher incidence in minority patients. Reports also highlight the importance of patient quality of life in late stages of cancer, as well as the effects on surrounding family and phys

* Information listed above is at the time of submission. *

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