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Enhanced recovery of disqualified donor organs using image-guided machine perfusion

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DK103475-01A1
Agency Tracking Number: R41DK103475
Amount: $207,603.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIDDK
Solicitation Number: PA14-072
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
165 CAMBRIDGE ST, STE 702
BOSTON, MA 02114-2748
United States
DUNS: 78670725
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MARIA-LOUIS IZAMIS
 (978) 807-8054
 mizamis@mgh.harvard.edu
Business Contact
 PAUL MAGNIN
Phone: (978) 807-8054
Email: paul.a.magnin@gmail.com
Research Institution
 MASSACHUSETTS GENERAL HOSPITAL
 
Partners Research Management 101 Huntington Ave, Suite 300
BOSTON, MA 02199-7603
United States

 () -
 Domestic nonprofit research organization
Abstract

DESCRIPTION (provided by applicant): In the United States alone, 76,000 lives are claimed by liver disease every year. Transplantation is currently the only established treatment, but there is a critical shortage of donor organs. More than 60% of candidates wait over a year to receive a transplant, the majority becoming too ill to tolerate the procedure. These numbers could be improved dramatically by expanding the available donor pool through the rescue of disqualified donor organs; conservatively estimated at 6,000 livers per year. We and others have shown experimentally that machine perfusion, an artificial body and blood supply for isolated donor organs, is a powerful methodology capable of administering treatment and significantly increasing viability.However, unlike tightly-controlled experimental livers, there is a large degre of variability that characterizes human donor organs, from a range of pre-existing comorbidities to the circumstances of death and the duration of warm and cold ischemia e

* Information listed above is at the time of submission. *

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