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Development of Compounds for the Prevention and Treatment of Rhabdomyolysis

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DK104638-01
Agency Tracking Number: R41DK104638
Amount: $374,051.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIDDK
Solicitation Number: PA14-054
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
115 PENN WARREN DRIVE SUITE 300-389
BRENTWOOD, TN 37027-5047
United States
DUNS: 799894931
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JOHN OATES
 (615) 343-4847
 john.oates@vanderbilt.edu
Business Contact
 R PORTER
Phone: (615) 445-5761
Email: virtualdoc@gmail.com
Research Institution
 VANDERBILT UNIVERSITY
 
VANDERBILT UNIVERSITY 1400 18th Ave South
NASHVILLE, TN 37212-2809
United States

 () -
 Nonprofit college or university
Abstract

? DESCRIPTION (provided by applicant): The goal of this Phase I STTR project is to establish the feasibility of developing a small-molecule therapeutic agent designed to prevent rhabdomyolysis-induced renal failure. Rhabdomyolysis accounts for 7% to 10% of cases of renal failure in the US. Rhabdomyolysis results from muscle injury that leads to the release of myoglobin, which is then deposited in the kidney. Acute renal injury and renal failure results. Often caused by crush injuries such as those thatoccur with earthquakes, explosive injuries (especially to military personnel) and other trauma, rhabdomyolysis also can result from hyperthermia, seizures, muscle ischemia, coma, or statin-induced myopathy. No effective means currently exist to prevent thekidney failure that results from rhabdomyolysis. Myoglobin deposited in the kidney undergoes redox cycling, generating radicals that produce lipid peroxidation-the products of which cause vasoconstriction and tubular necrosis. Consequently, the VDDI STTR

* Information listed above is at the time of submission. *

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