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Rapid Screening Assay for Novel Epigenetic Drugs

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41ES025597-01A1
Agency Tracking Number: R41ES025597
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIEHS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
4009 NE EMERSON ST
PORTLAND, OR 97211-8052
United States
DUNS: 78667905
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MICHAEL ROUNTREE
 (503) 201-6797
 mike.rountree@nzumbeinc.com
Business Contact
 TOMMY PHAM
Phone: (503) 201-6797
Email: tommy@nzumbeinc.com
Research Institution
 OREGON HEALTH AND SCIENCE UNIVERSITY
 
OREGON HEALTH AND SCIENCE UNIVERSITY 3181 SW Sam Jackson Pk Rd
PORTLAND, OR 97239-3098
United States

 () -
 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): A hallmark of virtually every cancer is aberrant epigenetic silencing of vital genes required for a normal cell cycle and genome stability (e.g. MLH1, BRCA1, VHL, p16, etc.). Loss of expression of these tumor suppressorgenes plays a critical role in cancer formation and growth. Thus, targeting this root cause of cancer has significant potential to treat and potentially cure a host of cancers. Indeed, a major initiative i essentially every major pharmaceutical company isto investigate epigenetic cancer therapies targeting the reactivation of these key genes. However, despite its promise, at this time drug-induced gene reactivation does not work therapeutically because reactivation is invariably unstable. One reason for this failure is that current approaches consider silencing as an end point instead of a process, and as a result do not strategically target epigenetic modifications that occur at different times during the silencing process. We believe achieving stabl

* Information listed above is at the time of submission. *

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