Using Structuring Interacting RNAs (sxRNAs) as microRNA Inhibitors

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41GM110877-01
Agency Tracking Number: R41GM110877
Amount: $224,609.00
Phase: Phase I
Program: STTR
Awards Year: 2014
Solicitation Year: 2014
Solicitation Topic Code: NIGMS
Solicitation Number: PA13-235
Small Business Information
170 CHESTNUT ST, ALBANY, NY, 12210-1906
DUNS: 808416700
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 SCOTT TENENBAUM
 (518) 437-8871
 stenenbaum@albany.edu
Business Contact
 EDWARD EVELETH
Phone: (518) 331-1133
Email: ted.eveleth@hocuslocus.com
Research Institution
 STATE UNIVERSITY OF NEW YORK AT ALBANY
 STATE UNIVERSITY OF NEW YORK AT ALBANY
OFFICE FOR SPONSORED PROGRAMS 1400 WASHINGTON AVE
ALBANY, NY, 12222-0001
 () -
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): We propose developing a trans-molecular RNA-switch for scientists to negatively affect the activity of endogenous microRNA for use as a molecular tool or therapeutic, an anti-miR. Since the discovery of miRNA, the creation of effective anti-miRs has been important, first to study and verify miRNA interactions, and, secondly, as a therapeutic tool. But, creating an effective anti-miR is not straightforward. At firt glance, one would thing that a strand of RNA in matchinglength and perfectly complementary in sequence would be the ideal anti-miR to fight for the attention of a particular miRNA and effectively neutralize it. However, a perfectly complementary sequence would induce the RISC complex and get cleaved rendering that strategy alone ineffective. While the backbone of the anti-miR can be modified, those modifications do not completely resolve this trade-off in complementariness and cleavage and add hepatoxicity issues to any therapeutic use of anti-miRs. We have

* Information listed above is at the time of submission. *

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