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Cblb-based Drugs Against Sepsis and Inflammation

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL118896-01A1
Agency Tracking Number: R41HL118896
Amount: $218,510.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA13-089
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
835 S WOLCOTT AVE, STE E334, 3RD FLOOR, (MC937)
CHICAGO, IL 60612-3748
United States
DUNS: 3736377
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 XIAO-PEI GAO
 (312) 996-8039
 XGAO@UIC.EDU
Business Contact
 XIAO GAO
Phone: (312) 355-1972
Email: info@cellbiologics.com
Research Institution
 UNIVERSITY OF ILLINOIS AT CHICAGO
 
UNIVERSITY OF ILLINOIS AT CHICAGO 310 AOB, M/C 672
CHICAGO, IL 60612-7224
United States

 () -
 Nonprofit college or university
Abstract

Abstract Septicemia poses a major health care challenge. Modern therapies requiring suppression of patients' immune systems, a growing numbers of elderly people in the population, and the emergence of drug-resistant bacteria, have increased the prevalenceand severity of the disease over the past few decades. Current treatments rely on drugs that do not significant reduce morbidity and mortality. We have discovered that the E3 ubiquitin ligase Cblb can be administered to mice to dramatically curb acute systemic inflammation and lung inflammatory injury in response to the endotoxin of Gram-negative bacteria. We have also delineated the fundamental signaling pathways at which Cblb acts in human cells and showed that its therapeutic benefit is dependent on itsE ligase activity. Thus, we now have the knowledge to exploit the therapeutic potential of Cblb as a drug. CellBiologics Inc. proposes to utilize a novel anti-inflammatory cell signaling pathway, i.e., a potential therapeutic human protein, Cblb, that can

* Information listed above is at the time of submission. *

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