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New generation of catheters for treatment of atrial fibrillation

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL120511-01A1
Agency Tracking Number: R41HL120511
Amount: $200,001.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
104 MODENA DR
CARY, NC 27513-1738
United States
DUNS: 30162602
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 NARINE SARVAZYAN
 (202) 994-0626
 phynas@gwu.edu
Business Contact
 KC ARMSTRONG
Phone: (919) 270-6874
Email: kc@nocturnalpd.com
Research Institution
 GEORGE WASHINGTON UNIVERSITY
 
OFFICE OF THE VICE PRESIDENT FOR RESEARCH 2121 EYE ST NW, STE 601
WASHINGTON, DC 20052-0001
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): Atrial fibrillation remains the most commonly occurring cardiac arrhythmia. It is associated with a lower quality of life and a higher rate of morbidity and mortality. Cryotherapy and radiofrequency catheter ablations for the purpose of eliminating atrial fibrillation have become a mainstream treatment option. They produce lesions that block the spread of electrical activity from the sites of abnormal activity, including the pulmonary veins. Today, there are limited means for real-time monitoring of tissue injury during cardiac ablation procedures. To address this need, we studied the fluorescence of endogenous NADH as a live marker of tissue injury during the ablation procedure and have confirmed the feasibility of thisapproach in blood perfused animal hearts. STTR Phase I support will provide us with the necessary funds to accelerate the project into its next phase. Studies will be conducted in small and large, fully-anesthetized open-chest animals. The goals of Aim1

* Information listed above is at the time of submission. *

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