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C/EBP-beta PEPTIDES FOR THE TREATMENT OF LUNG INJURY AND FIBROSIS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL122022-01A1
Agency Tracking Number: R41HL122022
Amount: $311,803.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
935 JEFFREY RD
DEL MAR, CA 92014-3912
United States
DUNS: 78673608
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 MARIO CHOJKIER
 (858) 552-8585
 mchojkier@gmail.com
Business Contact
 MARIO CHOJKIER
Phone: (858) 864-3588
Email: buckmartina@gmail.com
Research Institution
 VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
 
3350 LA JOLLA VILLAGE DR, 151A
SAN DIEGO, CA 92161-0002
United States

 () -
 Domestic nonprofit research organization
Abstract

DESCRIPTION (provided by applicant): Activation of lung myofibroblasts (LMF) is responsible for the development of lung fibrosis in chronic lung diseases of all causes and remarkably, LMF clearance by apoptosis may prevent development of lung fibrosis andlung injury, and possibly allow recovery from reversal of lung fibrosis. There is full agreement among tissue fibrosis experts that inhibiting o reversing myofibroblast activation (the therapeutic target) is critical fr the treatment of lung fibrosis. Bothpreventing progression of lung fibrosis as well as possibly, regression of lung fibrosis in spite of continued lung injury, as we clearly documented in our pre-clinical studies, are considered important clinical targets for patients with chronic lung disease and lung fibrosis. Finally, blocking the progression of lung fibrosis may decrease development of lung cancer. The basis for our Research and Development is the development of novel humanized C/EBP peptoids (not previously reported). We created a

* Information listed above is at the time of submission. *

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