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POC 2-D Diffusion Assay for self-monitoring of BNP

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL123871-01
Agency Tracking Number: R41HL123871
Amount: $177,631.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: HL14-017
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
637 STARMONT DR
DURHAM, NC 27705-2930
United States
DUNS: 78423830
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ASHUTOSH CHILKOTI
 (919) 660-5373
 info@sentilus.com
Business Contact
 ANGUS HUCKNALL
Phone: (252) 532-7135
Email: info@sentilus.com
Research Institution
 DUKE UNIVERSITY
 
DUKE UNIVERSITY 2200 W Main St, Suite 820
DURHAM, NC 27705-4673
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): The objective of this STTR proposal is to develop a 2-D diffusion point-of-care assay (POC) for B-type natriuretic peptide (BNP). The primary goal of the proposed work is to create a test format that will allow patientswith chronic heart failure to quantitatively self-monitor serum levels of BNP. Determination of baseline level of BNP and changes in this level over time have prognostic utility in patients presenting with acute coronary syndromes and acute heart failure, and data suggest that monitoring levels over time may be a useful adjunct to traditional clinical evaluation by chronic monitoring of volume status in heart failure patients and potentially in guiding their treatment. While the applications of point-of-car testing of BNP in the outpatient clinic setting are obvious, quantitative devices remain cumbersome and are not well suited to patient engagement in their own monitoring and care. In this proposal, we exploit technological advances that simplify re

* Information listed above is at the time of submission. *

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