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Enhancing mtDNA Repair During Stroke Reperfusion to Reduce Brain Damage

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41NS086267-01A1
Agency Tracking Number: R41NS086267
Amount: $224,989.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NINDS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
4526 KINGSWOOD DR
MOBILE, AL 36608-2814
United States
DUNS: 968503164
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 GLENN WILSON
 (251) 460-6765
 gwilson@southalabama.edu
Business Contact
 CHRISTINE CUMBIE
Phone: (251) 401-5186
Email: cchancery@exsciencorp.com
Research Institution
 MOREHOUSE SCHOOL OF MEDICINE
 
MOREHOUSE SCHOOL OF MEDICINE 720 Westview Dr SW
ATLANTA, GA 30310-1495
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): Attempts to develop drug treatments for acute stroke have not fulfilled expectations. Perhaps best illustrating this unsatisfactory situation is the hisory of therapeutic strategies directed at the inhibition of reactive oxygen species (ROS). While decades of laboratory and clinical studies make it clear that ROS are pathogenically important across the entire spectrum of cerebrovascular disease, as well as many other disorders, the beneficial effects of anti-oxidants inclinical trials for stroke have been unimpressive. These negative outcomes may be attributed in part to the heterogeneous nature of cerebral ischemia, which tends to obfuscate the design and interpretation of clinical trials. There also remains considerable scientific uncertainty about the molecular targets of anti-oxidant drug action. For example, non-selective antioxidants may disrupt signaling required for cell survival and recovery. The strategies currently available may not target the key sentinel

* Information listed above is at the time of submission. *

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