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Robotic whole organism HTS platform for drug discovery and development

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41TR000945-01A1
Agency Tracking Number: R41TR000945
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NCATS
Solicitation Number: PA13-235
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1120 15th Street, Ca-2105
AUGUSTA, GA 30912-0004
United States
DUNS: 170947977
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 JEFFREY MUMM
 (410) 502-2210
 jmumm@gru.edu
Business Contact
 MEERA SAXENA
Phone: (706) 721-9344
Email: meera@luminomics.com
Research Institution
 JOHNS HOPKINS UNIVERSITY
 
733 N. Broadway, Suite 117 Edward D. Miller Research Building
BALTIMORE, MD 21205-1832
United States

 () -
 Nonprofit college or university
Abstract

DESCRIPTION (provided by applicant): Our goal is to create a compact, affordable, fully automated, screening system for large-scale drug 2 testing in living small animal disease models (e.g., worms, flies, and fish). Modern drug discovery is 3 driven by high-throughput screening (HTS) systems that have the capacity to evaluate large chemical 4 compound 'libraries'. The majority of hits identified by in vitro HTS assays fail at animal testing stages 5 after significant investments in time and costs have already been made. This increase drug 6 development costs and presents a critical barrier to the discovery of novel therapies. A solution to this 7 problem is to integrate small animal disease models into HTS platforms at the earliest stage of the 8 discovery process. Powerful 'high-content' in vivo screening systems use automated imaging 9 processes to collect phenotypic data following drug exposures. However, these methods cannot attain 10 true HTS capacities and therefore cannot fully address current

* Information listed above is at the time of submission. *

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