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Transdermal Naltrexone for Opiate Addiction and Alcoholism

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 4R42DA032191-02
Agency Tracking Number: R42DA032191
Amount: $695,993.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NIDA
Solicitation Number: PA11-097
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1122 Oak Hill Dr
LEXINGTON, KY 40505-3322
United States
DUNS: 178031683
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 AUDRA STINCHCOMB
 (410) 706-2646
 astinchc@rx.umaryland.edu
Business Contact
 AUDRA STINCHCOMB
Phone: (859) 323-6192
Email: audra@alltranz.com
Research Institution
 SINCLAIR RESEARCH CENTER, LLC
 
SINCLAIR RESEARCH CENTER, LLC 562 STATE RT DD
AUXVASSE, MO 65231-
United States

 () -
 Domestic nonprofit research organization
Abstract

DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction. Naltrexone (NTX), an opioid antagonist, is currently used in oral tablet form to help maintain opioid addicts in a drug-free state. NTX is also FDA-approved for the treatment of alcohol dependence. Substantial clinical evidence exists for the benefits of NTX treatment in smoking cessation, especially in women. Very intriguing clinical trial data has also been observed in amphetamine-dependent individuals, which is especially important as methamphetamine dependence has no FDA-approved treatment options. Treatment with NTX in the 90's produced variable success rates in addicts; however, current clinical NTX therapy is being optimized based on human pharmacogenetic data. A 30-day depot injection of the drug has be

* Information listed above is at the time of submission. *

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