Virus-like-particle (VLP) vaccines for infectious bursal disease virus (IBDV).

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: 2014-00522
Agency Tracking Number: 2014-00522
Amount: $97,218.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 8.3
Solicitation Number: N/A
Timeline
Solicitation Year: 2014
Award Year: 2014
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
132 E LIBERTY ST, Wooster, OH, 44691-0000
DUNS: 079114429
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Linda Michel
 Project Director
 (330) 264-6441
 lmichel@laradinc.com
Business Contact
 Daral Jackwood
Title: President and Chief Science Officer
Phone: (330) 466-0411
Email: jackwood.2@osu.edu
Research Institution
 Stub
Abstract
Developing nations rely on poultry as their major protein source. Maintaining poultry health is of critical importance to good human nutrition worldwide. Infectious bursal disease is a contagious immunosuppressive disease affecting nearly all poultry producing regions of the world. The disease is caused by infectious bursal disease virus (IBDV) a bi-segmented double-stranded RNA virus. Vaccination of breeder flocks to produce maternal immunity in the chicks is used to control IBD. Control efforts are complicated by frequent genetic mutations, reassorting of genome segments and genetic recombination that can increase virulence and alter antigenicity which renders vaccines ineffective. The current practice of producing inactivated IBDV vaccines using virus grown in chicks is expensive and time consuming. We have demonstrated that in vitro production of multivalent virus-like-particles (VLPs) has the potential to solve these problems. The objectives of this project are to determine the optimal dosage of IBDV-VLP vaccines containing VP2 proteins from multiple antigenic strains of the virus and to complete safety and efficacy studies required for licensure by the USDA Center for Veterinary Biologics.

* Information listed above is at the time of submission. *

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