Novel 3-dimensional platform for high-throughput glycomics discovery

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$101,824.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43RR023763-01
Agency Tracking Number:
RR023763
Solicitation Year:
2007
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ADA TECHNOLOGIES, INC.
ADA TECHNOLOGIES, INC., 8100 SHAFFER PKWY, STE 130, LITTLETON, CO, 80127
Hubzone Owned:
N
Socially and Economically Disadvantaged:
Y
Woman Owned:
Y
Duns:
148034408
Principal Investigator:
XICHUN ZHOU
(303) 792-5615
xichunz@adatech.com
Business Contact:
SHERYL SUHR
(303) 792-5615
sheryls@adatech.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Glycomics is an emerging field that focuses on studying the interactions of carbohydrates with other biopolymers, particularly proteins, to gain a better understanding of the roles of carbohydrates in biological processes. Carbohydrate microarray technologies represent a new development at the frontier of glycomics. Microarrays of carbohydrates (glycoconjugates, polysaccharides, oligosaccharides and monosaccharides) allow high-throughput, parallel analyses. Parallel analyses greatly facilitate not only surveys of proteins for carbohydrate-binding activities but also elucidation of their ligands. However, there is a lack of technology for the fabrication of high quality carbohydrate microarrays for high-throughput analysis of glycomes because of the difficulty to reliably immobilize populations of chemically and structurally diverse glycans. ADA proposes to develop aminooxy- and hydrazide-functionalized dendrimer monolayer films on solid substrates for covalent, site-specific immobilization of unmodified carbohydrate probes. Miniaturized microwave radiation energy will also be evaluated for quick and convenient immobilization of the polysaccharides on the proposed slide platform. The resulting platforms will allow facile and effective fabrication of carbohydrate microarrays. The proposed novel slide platform will significantly increase the efficiency of glycan analysis and meet the growing needs of glycomics research and biomedical applications. Glycomics study the interactions of carbohydrates with other biopolymers, particularly proteins, to gain a better understanding of the roles of carbohydrates in biological processes. This proposed research seeks to develop a new tool for biologists to significantly increase the efficiency in glycan anaysis and meet the growing needs of glycomics research and biomedical applications.

* information listed above is at the time of submission.

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