SBIR Phase I: Silver Nanopillar patterned substrate for surface enhanced fluorescent detection of carbohydrate microarrays

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$99,984.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
0741155
Award Id:
88361
Agency Tracking Number:
0741155
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
8100 Shaffer Parkway, Suite #130, Littleton, CO, 80127
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
148034408
Principal Investigator:
Xichun Zhou
PhD
(303) 792-5615
xichunz@adatech.com
Business Contact:
Xichun Zhou
PhD
(303) 792-5615
xichunz@adatech.com
Research Institute:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase I research project aims to develop a carbohydrate microarray platform that takes advantage of the generation of surface plasmon by silver nanopillars to excite fluorophores above the surface of the microarray to perform detection of binding by proteins. A platform for querying the binding to carbohydrate moieties would open the door to a better understanding of the important role that carbohydrates play in the regulation of cell signaling and inter cellular communication. Such events not only play a role in the normal functions of the body, but are also intimately involved in the disease process. Currently the information regarding the interaction of proteins with carbohydrates is generated using techniques such as nuclear magnetic resonance (NMR). As mentioned above, the binding of proteins and carbohydrates constitutes a very important biological phenomenon, and thus the development of a carbohydrate microarray for querying such binding events would be of significant value to the scientific community.

* information listed above is at the time of submission.

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