SBIR Phase I: Silver Nanopillar patterned substrate for surface enhanced fluorescent detection of carbohydrate microarrays

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0741155
Agency Tracking Number: 0741155
Amount: $99,984.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solicitation Year: N/A
Solicitation Topic Code: BT
Solicitation Number: NSF 07-551
Small Business Information
8100 Shaffer Parkway, Suite #130, Littleton, CO, 80127
DUNS: 148034408
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Xichun Zhou
 (303) 792-5615
Business Contact
 Xichun Zhou
Title: PhD
Phone: (303) 792-5615
Research Institution
This Small Business Innovation Research (SBIR) Phase I research project aims to develop a carbohydrate microarray platform that takes advantage of the generation of surface plasmon by silver nanopillars to excite fluorophores above the surface of the microarray to perform detection of binding by proteins. A platform for querying the binding to carbohydrate moieties would open the door to a better understanding of the important role that carbohydrates play in the regulation of cell signaling and inter cellular communication. Such events not only play a role in the normal functions of the body, but are also intimately involved in the disease process. Currently the information regarding the interaction of proteins with carbohydrates is generated using techniques such as nuclear magnetic resonance (NMR). As mentioned above, the binding of proteins and carbohydrates constitutes a very important biological phenomenon, and thus the development of a carbohydrate microarray for querying such binding events would be of significant value to the scientific community.

* Information listed above is at the time of submission. *

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