A METAL-OXIDE CHARACTERISTIC-LINE X-RAY IMAGING SOURCE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
8058
Agency Tracking Number:
8058
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
532 Emerson St, Palo Alto, CA, 94301
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
THERE IS A NEED FOR A CORONARY-ARTERY DISEASE SCREENING METHOD NOT REQUIRING THE RISK OF AN ARTERIAL CATHETER. DIGITAL-SUBTRACTION RADIOGRAPHS USING IODINE-K-EDGE SUBTRACTION SUFFER FROM LOW X-RAY INTENSITIES AND REQUIRE LARGE IODINE CONCENTRATIONS PRECLUDING NON-INVASIVE TECHNIQUES. BRIGHTER X-RAY SOURCES ARE NEEDED. WE PROPOSE TO CONDUCT AN EVALUATION OF METAL OXIDES AS CHARACTERISTIC-LINE X-RAY EMITTERS. TWO TYPES OF DEVICES WILL BE CONSIDERED:(1) A HIGH-CURRENT PULSED X-RAY GUN WITH A METAL-OXIDE-COATED THIN-TARGET WINDOW, (2) A COMMERCIALLY AVAILABLE X-RAY TUBE WITH A MODIFIED METAL-OXIDE-COATED ROTATING ANODE. THESE SOURCES ARE EXPECTED TO PRODUCE A USEFUL FLUX FOR K-EDGE DICHROMOGRAPHY OF APPROXIMATELY 50 TIMES GREATER THAN THAT OF FILTERED BREMSSTRAH-LUNG. WE HAVE ALSO DEVELOPED A COMPUTER SIMULATION OF IODINE-K-EDGE DICHROMOGRAPHY WHICH DETERMINES THE X-RAY FLUX NEEDED FROM IMAGING WITH A PARTICULAR X-RAY-DETECTOR SYSTEM. THIS SIMULATION TOGETHER WITH AN ESTIMATE OF THE CHARACTERISTIC-LINE X-RAY PRODUCTION OF OUR SOURCES, INDICATE THAT IODINE-K-EDGE DICHROMOGRAPHY IS POSSIBLE. WE WILL HAVE AT OUR DISPOSAL CRITICAL RESEARCH FACILITIES OF VARIAN ASSOCIATES, THE STANFORD LINEAR ACCELERATOR CENTER, AND ADELPHI TECHNOLOGY INC. THIS INCLUDES X-RAY DETECTION EQUIPMENT, X-RAY SOURCES, AND VAPOR-DEPOSITION FACILITIES. WE HAVE DEVELOPED A DIGITAL X-RAY-IMAGING SYSTEM WHICH IS ALSO AVAILABLE FOR THIS WORK. ADELPHI TECHNOLOGY INC. HAS EXTENSIVE EXPERIENCE DEVELOPING ADVANCED X-RAY SOURCES FOR MEDICAL, SCIENTIFIC, AND INDUSTRIAL APPLICATIONS. A MEDICALDIAGNOSTIC IMAGING SYSTEM BASED UPON THE CHARACTERISTIC-LINESOURCE BEING DEVELOPED HERE PROMISES A MODERATE-COST NON-INVASIVE METHOD FOR SCREENING ATHEROSCLEROSIS.

* information listed above is at the time of submission.

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