THE SURFACE PLASMON IMMUNOASSAY FOR MEASUREMENT OF HCG

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,963.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
16491
Agency Tracking Number:
16491
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
285 Hamilton Avenue, Suite 430, Palo Alto, CA, 94301
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Fontana, Eduardo
Principal Investigator
(415) 328-7337
Business Contact:
1 R43 HD28542-01
() -
Research Institution:
n/a
Abstract
THE SURFACE PLASMON RESONANCE PHENOMENON WILL BE EXPLORED TO DEVELOP A QUANTITATIVE, SENSITIVE, ASSAY SYSTEM FOR REPRODUCTIVE HORMONES OF CLINICAL INTEREST. THE APPROACH CAN ATTAIN, WITH RELATIVELY INEXPENSIVE INSTRUMENTATION, A SENSITIVITY LIMIT COMPARABLE TO EXISTING ASSAY METHODOLOGIES, WITHOUT THE USE OF DYES, RADIOISOTOPES OR ENZYMES FOR SPECIFIC SIGNAL GENERATION. PART OF THE PHASE I RESEARCH WORK WILL ENTAIL CHOICE OF REAGENTS AND DEVELOPMENT OF A COMPACT OPTICAL INSTRUMENT FOR PERFORMING HORMONE QUANTIFICATIONS OF SERUM SAMPLES USING THE SURFACE PLASMON IMMUNOASSAY (SPI). DURING THIS STAGE OF THE RESEARCH, HUMAN CHORIONIC GONADOTROPIN (HCG), WILL BE USED AS A MODEL HORMONE TO CHARACTERIZE THE ASSAY PERFORMANCE IN TERMS OF SENSITIVITY, SPECIFICITY, ACCURACY, AND REPRODUCIBILITY. IN THE PHASE II STUDY, THE APPROACH WILL BE EXTENDED TO INCLUDE OTHER HORMONES OF CLINICAL INTEREST AND THE POSSIBILITY FOR REAL-TIME HORMONE QUANTIFICATION WILL BE INVESTIGATED.

* information listed above is at the time of submission.

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