Surface Plasmon Fiber Sensor for Antibody Detection

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI36837-1,
Agency Tracking Number: 24804
Amount: $53,990.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Adelphi Technology Inc.
2181 Park Boulevard, Palo Alto, CA, 94306
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Eduardo Fontana
 (415) 328-7337
Business Contact
Phone: () -
Research Institution
We will develop a new fiber sensor technology based on detection of SP oscillations with thespecific goal of designing a simple, low-cost, remote optical probe capable of measuring HIV and otherviral antibodies upon direct contact with a suitable biological fluid. The sensor will be capable ofdetecting a specific immunological reaction between proteins immobilized onto the fiber sensor and theircorresponding binding partners in solution, without the requirements of molecular tagging employed inconventional immunoassay procedures. Therefore, the proposed technology will be important for invitro, ex vivo, and in vivo diagnosis of infectious agents. In Phase I, we will carry out research tounderstand and control the SP oscillations in optical fibers. The feasibility for immunosensingapplications will be tested by use of a model system composed of human chorionic gonadotropin (HCG)molecules immobilized on the sensor tip for specific determination of low concentrations of anti-HCGin solution. Phase II research will use the technology developed in Phase I study to build a prototypedevice sensitive enough to measuring viral antibodies in saliva. The analyte menu will include HIV,hepatitis, leukemia, and other viral antibodies of interest in the diagnostics of infectious diseases.

* information listed above is at the time of submission.

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