Dark-Field Hard-X-ray Microscope

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
1R43RR022910-01
Award Id:
75588
Agency Tracking Number:
RR022910
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Adelphi Technology, Inc., 981-B Industrial Rd, San Carlos, CA, 94070
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MELVIN PIESTRUP
(650) 598-9800
melpie@adelphitech.com
Business Contact:
CHARLES GRAY
(650) 598-9800
CGARY@ADELPHITECH.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase 1 project will develop a hard-x-ray microscope capable of producing dark-field images for the detection of colloidal gold particles. Gold colloidal particles are used as labels in the study of antigens and cell and protein structure. In prior research, Adelphi Technology Inc. has developed compound refractive lenses for use in an x-ray microscope that has been used to image biological material in the bright-field mode. A prototype dark-field microscope will be developed by modifying this existing microscope. The potential for successful development of the prototype imaging system is very high because prior work by other researchers using synchrotron sources that have demonstrated the ability to detect gold particle sizes down to 20 nm in very thin specimens. The use of harder x-rays promises detection of smaller size particles inside thicker specimens and the possibility of the use of tomography for volume analysis. Replacing the synchrotron with a conventional x-ray tube as the x-ray source permits commercial and scientific use outside national laboratories. Issues to be explored in Phase I include: adequacy of x-ray source intensity, dose to specimen, expected contrast, and resolution.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government